BridgeBio bounces back? Phase 2 readout provides hope for approval of drug to rebalance calcium levels

After a series of unfortunate events for BridgeBio Pharma, the biotech may be on a new upward trajectory as it unveiled positive data from 13 patients taking a drug to treat low calcium levels. 

BridgeBio shared the phase 2b results this week at the 2022 Annual Meeting of the Endocrine Society held in Atlanta, which showed that the drug, encaleret, restored normal calcium and phosphate metabolism in individuals with a rare genetic condition called autosomal dominant hypocalcemia type 1 (ADH1).

The positive data follow a phase 3 flop in late 2021 for Bridge Bio’s lead asset acoramidis, along with subsequent rounds of layoffs and a tumbling share price. 

However, things might be on an upswing for BridgeBio. After cutting down its clinical programs and putting six of its candidates on the block for out-licensing opportunities, the biotech is pinning its hopes on potential value driver encaleret. The oral medicine is being studied in disorders of calcium homeostasis, including ADH1, a condition that is typically inherited and can cause physical, cognitive and emotional symptoms including poor memory, loss of consciousness and seizures.

Click here to read the full article at Fierce Biotech

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