Moderna Announces First Patient Dosed in Phase 1/2 Study of mRNA-3705 for Methylmalonic Acidemia

Moderna, Inc.  (Nasdaq: MRNA) a clinical stage biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines, today announced the first patient has been enrolled in the Phase 1/2 study evaluating the safety and tolerability of mRNA-3705, its investigational mRNA therapeutic for methylmalonic acidemia (MMA), administered via intravenous infusion in patients with isolated MMA due to MUT deficiency.

“We would like to thank Dr. Santra and the whole team in Birmingham for their efforts and collaboration to achieve this milestone moment of dosing the first MMA patient with our mRNA therapeutic,” said Ruchira Glaser, M.D., Sr. Vice President and Therapeutic Area Head, Rare Disease, Autoimmune & Cardiovascular. “This is another step forward in Moderna’s mission to deliver on the promise of mRNA science to create a new generation of transformative medicines for patients.”

“We are delighted to have been able to treat the first patient in the world with this new medicine here in Birmingham,” Saikat Santra, M.D., Pediatric Inherited Metabolic Medicine Consultant, Clinical Inherited Metabolic Disorders at Birmingham Women’s and Children’s NHS Foundation Trust. “We sincerely hope that it brings this brave patient, and many more like them, a brighter future free of the restrictions of this terrible disease.”

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